Journal
Current rheumatology reports
Alternate Journal
Curr Rheumatol Rep

Dermatomyositis is a poorly understood multisystem disease predominantly affecting skin and muscle. This review focuses on the potential role of a group of related cytokines, the type 1 interferons, in the pathogenesis of dermatomyositis. Type 1 interferon-inducible transcripts and proteins are uniquely elevated in dermatomyositis muscle compared with all other muscle diseases studied to date. The endothelial cell tubuloreticular inclusions present in affected dermatomyositis muscle are biomarkers of type 1 interferon exposure. The cell-poor lichenoid reaction in skin with predominant involvement of the basal epidermal cell layer and its topologic equivalent in muscle, perifascicular atrophy, may be lesions that develop directly in response to type 1 interferon signaling.

Greenberg SA. Dermatomyositis and type 1 interferons. Current rheumatology reports. 2010;12(3):198-203. doi:10.1007/s11926-010-0101-6.
3
06/2010
10.1007/s11926-010-0101-6
1534-6307
198-203
12