The positions are available for highly motivated and skilled individuals with expertise in next generation sequencing (NGS) analysis and statistical genomics. Dr. Kong’s group in the Computational Health Informatics Program at Boston Children’s Hospital, Boston, MA, USA are looking for enthusiastic and talented genome scientists at various levels (post-docs and research scientists). We seek to improve current clinical practices by providing expertise and insight from large-­scale and multi­dimensional analysis of multi-­omics datasets from patients with diverse disorders.

PRIMARY DUTIES AND RESPONSIBILITIES:

  • ­  Develop novel computational and bioinformatic tools for genomic analysis.
  • ­  Statistical analysis of genomic and clinical datasets from case­-control and cohort studies and interpret the results accordingly.
  • ­  Work independently on multiple ongoing projects with flexibility to adjust to new priorities.
  • ­  Cross­-training bioinformatic colleagues.
  • ­  Present the work in form of scientific publications and oral communications to the scientific community.

The group is located at the Boston Children’s Hospital, a teaching hospital affiliated with Harvard University. 

Qualifications
  • ­Strong proficiency with R, python and other programming languages.
  • ­Familiarity with modern statistical analysis paradigms with high-­dimensional data is required.
  • ­Strong communication skills and ability to effectively translate scientific concepts to multidisciplinary personnel.
  • Demonstrated ability developing analysis schemes for whole­-genome sequencing (WGS), RNA­-Seq and epigenomic profiles.
  • Deep understanding of genomics and molecular biology.
  • Highly proficient in spoken and written English and scientific writing skills.

The candidates for post-docs or research scientists must hold a Ph.D. or equivalent degree by the start of employment.

How to apply

Interested applicants should send a cover letter outlining research experience and interests, curriculum vitae (CV), and the names and contacts of three referees to Dr. Sek Won Kong (sekwon.kong@childrens.harvard.edu).

Publications

Morales A, Ing A, Antolik C, Austin-Tse C, Baudhuin LM, Bronicki L, Cirino A, Hawley MH, Fietz M, Garcia J, Ho C, Ingles J, Jarinova O, Johnston T, Kelly MA, Kurtz CL, Lebo M, Macaya D, Mahanta L, Maleszewski J, Manrai AK, Murray M, Richard G, Semsarian C, Thomson KL, Winder T, Ware JS, Hershberger RE, Funke BH, Vatta M, . Harmonizing the Collection of Clinical Data on Genetic Testing Requisition Forms to Enhance Variant Interpretation in Hypertrophic Cardiomyopathy (HCM): A Study from the ClinGen Cardiomyopathy Variant Curation Expert Panel. The Journal of molecular diagnostics : JMD 2021.

Kohane IS, Aronow BJ, Avillach P, Beaulieu-Jones BK, Bellazzi R, Bradford RL, Brat GA, Cannataro M, Cimino JJ, García-Barrio N, Gehlenborg N, Ghassemi M, Gutiérrez-Sacristán A, Hanauer DA, Holmes JH, Hong C, Klann JG, Loh NHW, Luo Y, Mandl KD, Mohamad D, Moore JH, Murphy SN, Neuraz A, Ngiam KY, Omenn GS, Palmer N, Patel LP, Pedrera-Jiménez M, Sliz P, South AM, Tan ALM, Taylor DM, Taylor BW, Torti C, Vallejos AK, Wagholikar KB, Weber GM, Cai T. What Every Reader Should Know About Studies Using Electronic Health Record Data but May be Afraid to Ask. Journal of medical Internet research 2021.

Cutillo CM, Sharma KR, Foschini L, Kundu S, Mackintosh M, Mandl KD, . Machine intelligence in healthcare-perspectives on trustworthiness, explainability, usability, and transparency. NPJ digital medicine 2020.

Brat GA, Weber GM, Gehlenborg N, Avillach P, Palmer NP, Chiovato L, Cimino J, Waitman LR, Omenn GS, Malovini A, Moore JH, Beaulieu-Jones BK, Tibollo V, Murphy SN, Yi SL, Keller MS, Bellazzi R, Hanauer DA, Serret-Larmande A, Gutierrez-Sacristan A, Holmes JJ, Bell DS, Mandl KD, Follett RW, Klann JG, Murad DA, Scudeller L, Bucalo M, Kirchoff K, Craig J, Obeid J, Jouhet V, Griffier R, Cossin S, Moal B, Patel LP, Bellasi A, Prokosch HU, Kraska D, Sliz P, Tan ALM, Ngiam KY, Zambelli A, Mowery DL, Schiver E, Devkota B, Bradford RL, Daniar M, Daniel C, Benoit V, Bey R, Paris N, Serre P, Orlova N, Dubiel J, Hilka M, Jannot AS, Breant S, Leblanc J, Griffon N, Burgun A, Bernaux M, Sandrin A, Salamanca E, Cormont S, Ganslandt T, Gradinger T, Champ J, Boeker M, Martel P, Esteve L, Gramfort A, Grisel O, Leprovost D, Moreau T, Varoquaux G, Vie JJ, Wassermann D, Mensch A, Caucheteux C, Haverkamp C, Lemaitre G, Bosari S, Krantz ID, South A, Cai T, Kohane IS. International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. NPJ digital medicine 2020.