BCH AI and Machine Learning Journal Club: Arjun Manrai, PhD

Speaker: Arjun (Raj) Manrai, PhD, at Boston Children's Hospital

Date: May 8, 2020 at 09:30AM - 10:30AM

Blood laboratory measures such as glucose and hemoglobin are the basis for much of clinical decision making, yet baseline variation for many laboratory measures remains incompletely characterized across age, gender, and race groups. I will introduce foundational techniques from machine learning and statistical genetics and show how they can be applied to systematically unpack variation in blood laboratory data across population groups. These analyses reveal widespread demographic structure in blood laboratory data.

Blood laboratory measures such as glucose and hemoglobin are the basis for much of clinical decision making, yet baseline variation for many laboratory measures remains incompletely characterized across age, gender, and race groups. Dr. Manrai introduced foundational techniques from machine learning and statistical genetics and showed how they can be applied to systematically unpack variation in blood laboratory data across population groups. These analyses reveal widespread demographic structure in blood laboratory data.


Publications

Chen KY, Borglund EM, Postema EC, Dunn AG, Bourgeois FT. Reporting of clinical trial safety results in ClinicalTrials.gov for FDA-approved drugs: A cross-sectional analysis. Clinical trials (London, England) 2022.

Le Naour J, Sztupinszki Z, Carbonnier V, Casiraghi O, Marty V, Galluzzi L, Szallasi Z, Kroemer G, Vacchelli E. A loss-of-function polymorphism in compromises therapeutic outcome in head and neck carcinoma patients. Oncoimmunology 2022.

Klann JG, Strasser ZH, Hutch MR, Kennedy CJ, Marwaha JS, Morris M, Samayamuthu MJ, Pfaff AC, Estiri H, South AM, Weber GM, Yuan W, Avillach P, Wagholikar KB, Luo Y, Omenn GS, Visweswaran S, Holmes JH, Xia Z, Brat GA, Murphy SN. Distinguishing Admissions Specifically for COVID-19 from Incidental SARS-CoV-2 Admissions: A National Retrospective EHR Study. Journal of medical Internet research 2022.