Let us get practical: developing and disseminating AI research and workflows to audiences of researchers and clinicians within BCH using the ChRIS platform

Speaker: Rudolph Pienaar, PhD, at Boston Children's Hospital

Date: January 29, 2021 at 09:30AM - 10:30AM

We are often wowed by the *potential* of AI (and frankly other sophisticated computational approaches) to transform research and clinical workflows. New approaches seem to magically hold unbounded promise. Yet, there is often a large gulf between theory and practice, between a shiny new technique and having anyone just use it. The questions of "How do I get this ? How do I get my data from PACS to connect to this? How do I go from DICOM to something that the neural network wants? How do I get results that are useful?" In this talk I will provide some insights into practically developing, using, and disseminating "AI" (and other) workflows in the BCH clinical and research environment.

Dr. Rudolph Pienaar is currently faculty Staff Scientist at Boston Children's Hospital, where he is the Technical Director of the Fetal-Neonatal Neuroimaging and Development Science Center (FNNDSC). The Center aims to play both a research and clinical role in the Boston’s Children's Hospital, and in his capacity at the Center he is engaged in both translational as well as applied research. The goal of the translational research component is to rapidly prototype and deploy complex research-based software within a clinical setting. To this end he heads up a small team developing simple interfaces to creating, managing, and using a wide array of research software, as well as optimizing design and execution of the same. His applied research explores and models the basic processes underpinning human brain development, especially the shape of cortical surfaces and the role this can play in development and disease. Related interests are white matter tractography, specifically the propagation and flow of information through brain networks, as well as investigating relationships between cortical surface markers and internal fiber organization.


Publications

Levy S, Wisk LE, Chadi N, Lunstead J, Shrier LA, Weitzman ER. Validation of a single question for the assessment of past three-month alcohol consumption among adolescents. Drug and alcohol dependence 2021.

Wu F, Xiao A, Zhang J, Moniz K, Endo N, Armas F, Bonneau R, Brown MA, Bushman M, Chai PR, Duvallet C, Erickson TB, Foppe K, Ghaeli N, Gu X, Hanage WP, Huang KH, Lee WL, Matus M, McElroy KA, Nagler J, Rhode SF, Santillana M, Tucker JA, Wuertz S, Zhao S, Thompson J, Alm EJ. SARS-CoV-2 RNA concentrations in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases. The Science of the total environment 2021.

Weber GM, Zhang HG, L'Yi S, Bonzel CL, Hong C, Avillach P, Gutiérrez-Sacristán A, Palmer NP, Tan AL, Wang X, Yuan W, Gehlenborg N, Alloni A, Amendola DF, Bellasi A, Bellazzi R, Beraghi M, Bucalo M, Chiovato L, Cho K, Dagliati A, Estiri H, Follett RW, García-Barrio N, Hanauer DA, Henderson DW, Ho YL, Holmes JH, Hutch MR, Kavuluru R, Kirchoff K, Klann JG, Krishnamurthy AK, Le TT, Liu M, Loh NHW, Lozano-Zahonero S, Luo Y, Maidlow S, Makoudjou A, Malovini A, Moal B, Morris M, Mowery DL, Murphy SN, Neuraz A, Ngiam KY, Okoshi MP, Omenn GS, Patel LP, Pedrera-Jiménez M, Prudente RA, Samayamuthu MJ, Sanz J, Schriver ER, Schubert P, Serrano-Balazote P, Tan BW, Tanni SE, Tibollo V, Visweswaran S, Wagholikar KB, Xia Z, Zöller D, Kohane IS, Cai T, South AM, Brat GA. International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: a 4CE Consortium Study. Journal of medical Internet research 2021.

Mandl KD, Perakslis ED. HIPAA and the Leak of "Deidentified" EHR Data. Reply. The New England journal of medicine 2021.

Rees CA, Monuteaux MC, Herdell V, Fleegler EW, Bourgeois FT. Correlation Between National Institutes of Health Funding for Pediatric Research and Pediatric Disease Burden in the US. JAMA pediatrics 2021.