Real-world COVID-19 Vaccine Effectiveness and the Mass Vaccination Experience in Israel

Speaker: Ben Reis, PhD, at Harvard Medical School

Date: March 16, 2021 at 2:00PM - 3:00PM

Dr. Ben Reis will lead a discussion on the recent New England Journal of Medicine paper he co-authored, providing the first real-world study of effectiveness of the Pfizer-BioNTech COVID-19 vaccine. It was the largest study yet to quantify the impact of the vaccine outside the confines of a clinical trial. The study used innovative epidemiological methods to analyze vaccine effectiveness for preventing symptomatic diseases, severe illness and death. Dr. Reis will discuss his study and the lessons learned from the nation-wide mass vaccination experience in Israel. The study has been featured in The New York TimesBloomberg, and Fortune.

Dr. Ben Reis is Director of the Predictive Medicine Group at Harvard Medical School and the Children’s Hospital Informatics Program. His research focuses on understanding the essential patterns of human disease, and on developing novel approaches for predicting disease. He has created systems that allow doctors to predict dangerous clinical conditions years in advance, as well as predictive pharmacology systems that allow public health officials to identify life-threatening adverse drug effects years in advance. Dr. Reis has designed predictive health monitoring systems for regional and national settings, and has advised governments worldwide on establishing biodefense and biosurveillance infrastructures. He has been recognized by the White House for his work on harnessing social networks to promote health, and by the US State Department, USAID and NASA for his work in global health innovation.


Publications

Levy S, Wisk LE, Chadi N, Lunstead J, Shrier LA, Weitzman ER. Validation of a single question for the assessment of past three-month alcohol consumption among adolescents. Drug and alcohol dependence 2021.

Wu F, Xiao A, Zhang J, Moniz K, Endo N, Armas F, Bonneau R, Brown MA, Bushman M, Chai PR, Duvallet C, Erickson TB, Foppe K, Ghaeli N, Gu X, Hanage WP, Huang KH, Lee WL, Matus M, McElroy KA, Nagler J, Rhode SF, Santillana M, Tucker JA, Wuertz S, Zhao S, Thompson J, Alm EJ. SARS-CoV-2 RNA concentrations in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases. The Science of the total environment 2021.

Weber GM, Zhang HG, L'Yi S, Bonzel CL, Hong C, Avillach P, Gutiérrez-Sacristán A, Palmer NP, Tan AL, Wang X, Yuan W, Gehlenborg N, Alloni A, Amendola DF, Bellasi A, Bellazzi R, Beraghi M, Bucalo M, Chiovato L, Cho K, Dagliati A, Estiri H, Follett RW, García-Barrio N, Hanauer DA, Henderson DW, Ho YL, Holmes JH, Hutch MR, Kavuluru R, Kirchoff K, Klann JG, Krishnamurthy AK, Le TT, Liu M, Loh NHW, Lozano-Zahonero S, Luo Y, Maidlow S, Makoudjou A, Malovini A, Moal B, Morris M, Mowery DL, Murphy SN, Neuraz A, Ngiam KY, Okoshi MP, Omenn GS, Patel LP, Pedrera-Jiménez M, Prudente RA, Samayamuthu MJ, Sanz J, Schriver ER, Schubert P, Serrano-Balazote P, Tan BW, Tanni SE, Tibollo V, Visweswaran S, Wagholikar KB, Xia Z, Zöller D, Kohane IS, Cai T, South AM, Brat GA. International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: a 4CE Consortium Study. Journal of medical Internet research 2021.

Mandl KD, Perakslis ED. HIPAA and the Leak of "Deidentified" EHR Data. Reply. The New England journal of medicine 2021.

Rees CA, Monuteaux MC, Herdell V, Fleegler EW, Bourgeois FT. Correlation Between National Institutes of Health Funding for Pediatric Research and Pediatric Disease Burden in the US. JAMA pediatrics 2021.