The Age of Predictive Medicine

Speaker: Ben Reis, PhD, at Boston Children's Hospital

Date: October 16, 2020 at 09:30AM - 10:30AM

Dr. Ben Reis discussed recent developments in machine learning approaches to some of the grandest challenges of human health, including pandemic prediction, suicide prevention, bioterrorism detection, and drug safety prediction. The focus was on understanding both the methodological challenges involved and the ramifications of generating actionable predictions in these critical areas. The talk concluded by formulating a set of central challenges and opportunities facing the field of Predictive Medicine.

Dr. Ben Reis is the Director of the Predictive Medicine Group at the Computational Health Informatics Program at Boston Children's Hospital and Harvard Medical School. His research focuses on understanding the fundamental patterns of human disease and on developing novel approaches for predicting disease. He has created systems that allow doctors to predict dangerous clinical conditions years in advance, including suicide and domestic abuse, as well as predictive pharmacology systems that allow drug safety professionals to identify life-threatening adverse drug effects years in advance. Dr. Reis has advised the US government on establishing national biodefense systems in the wake of the 9/11 attacks, the Hong Kong government on building health infrastructure in response to the SARS pandemic, the Greek government on establishing biodefense systems for the Athens Summer Olympics, and the Chinese Government in advance of the Beijing Summer Olympics. He has been honored at the White House for his work on harnessing social networks to promote health, and was named one of the top health innovators in the world by the US State Department and NASA.


Publications

Hopper RK, Abman SH, Elia EG, Avitabile CM, Yung D, Mullen MP, Austin ED, Bates A, Handler SS, Feinstein JA, Ivy DD, Kinsella JP, Mandl KD, Raj JU, Sleeper LA, . Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry. The Journal of pediatrics 2022.

Wang X, Zhang HG, Xiong X, Hong C, Weber GM, Brat GA, Bonzel CL, Luo Y, Duan R, Palmer NP, Hutch MR, Gutiérrez-Sacristán A, Bellazzi R, Chiovato L, Cho K, Dagliati A, Estiri H, García-Barrio N, Griffier R, Hanauer DA, Ho YL, Holmes JH, Keller MS, Klann MEng JG, L'Yi S, Lozano-Zahonero S, Maidlow SE, Makoudjou A, Malovini A, Moal B, Moore JH, Morris M, Mowery DL, Murphy SN, Neuraz A, Yuan Ngiam K, Omenn GS, Patel LP, Pedrera-Jiménez M, Prunotto A, Jebathilagam Samayamuthu M, Sanz Vidorreta FJ, Schriver ER, Schubert P, Serrano-Balazote P, South AM, Tan ALM, Tan BWL, Tibollo V, Tippmann P, Visweswaran S, Xia Z, Yuan W, Zöller D, Kohane IS, Avillach P, Guo Z, Cai T, . SurvMaximin: Robust federated approach to transporting survival risk prediction models. Journal of biomedical informatics 2022.

Torous J, Stern AD, Bourgeois FT. Regulatory considerations to keep pace with innovation in digital health products. NPJ digital medicine 2022.

Levy S, Wisk LE, Minegishi M, Ertman B, Lunstead J, Brogna M, Weitzman ER. Association of Screening and Brief Intervention With Substance Use in Massachusetts Middle and High Schools. JAMA network open 2022.

Nielsen M, Presti M, Sztupinszki Z, Jensen AWP, Draghi A, Chamberlain CA, Schina A, Yde CW, Wojcik J, Szallasi Z, Crowther MD, Svane IM, Donia M. Co-existing alterations of MHC class I antigen presentation and IFNγ signaling mediate acquired resistance of melanoma to post-PD-1 immunotherapy. Cancer immunology research 2022.