Upcoming Lectures

Landmark Ideas Series: Ray Kurzweil

Speaker: Ray Kurzweil, Inventor and Futurist at Google and Kurzweil AI

Date: December 5, 2022 at 4:00PM - 5:00PM

Talk Topic: Rewriting Biology with Artificial Intelligence.

Landmark Ideas Series: Dr. Rich Miner

Speaker: Rich Miner, PhD, Android Co-founder; Co-founder at GV

Date: January 12, 2023 at 4:00PM - 5:30PM

Dr. Mandl and Dr. Miner will have a fireside chat.

Landmark Ideas Series: Prof. Allan Brandt

Speaker: Allan Brandt, PhD, Leading Historian of Medicine and Science. University Professor at Harvard University

Date: February 9, 2023 at 4:00PM - 5:30PM

Talk details will be forthcoming.

Landmark Ideas Series: Dr. Ran Balicer

Speaker: Ran Bailcer, MD, PhD, Chief Innovation Officer at Clalit Health Services

Date: March 2, 2023 at 4:00PM - 5:30PM

Talk details will be forthcoming.

Landmark Ideas Series: Dr. Julie Gerberding

Speaker: Julie Gerberding, MD, MPH, CEO at Foundation for the National Institutes of Health, Former Director, CDC

Date: April 3, 2023 at 4:00PM - 5:30PM

Talk details will be forthcoming.

Landmark Ideas Series: Karen Copenhaver

Speaker: Karen Copenhaver, Legal Counsel at The Linux Foundation

Date: May 1, 2023 at 4:00PM - 5:30PM

Talk Topic: Using Licensing to Maximize Innovation in The Open Source Software Ecosystem.

Landmark Ideas Series: Dr. Robert Langer

Speaker: Robert Langer, ScD, Institute Professor at MIT; most cited engineer in history

Date: September 7, 2023 at 4:00PM - 5:30PM

Talk details will be forthcoming.

Landmark Ideas Series: Dr. W. Ian Lipkin

Speaker: W. Ian Lipkin, MD, Renowned virus hunter and Director for the Center of Infection and Immunity at Columbia University

Date: October 5, 2023 at 4:00PM - 5:30PM

Talk details will be forthcoming.

Landmark Ideas Series: Dr. Thom Mayer

Speaker: Thom Mayer, MD, FACEP, FAAP, FACHE, Medical Director at NFL Players Association

Date: December 7, 2023 at 4:00PM - 5:30PM

Talk details will be forthcoming.

Landmark Ideas Series: Dr. Mollyann Brodie

Speaker: Mollyann Brodie, PhD, Director of Public Opinion and Survey Research Program at the Kaiser Family Foundation

Date: January 29, 2024 at 4:00PM - 5:30PM

Talk details will be forthcoming.

Landmark Ideas Series: Dr. Toby Cosgrove

Speaker: Toby Cosgrove, MD, Former CEO and current Executive Advisor at the Cleveland Clinic

Date: February 12, 2024 at 4:00PM - 5:30PM

Talk details will be forthcoming.

Past Lectures

Intelligent Health Lab Series: Dr. Nathan Kuppermann

Speaker: Nate Kuppermann, MD, MPH, Distinguished Professor, Departments of Emergency Medicine and Pediatrics; Associate Dean for Global Health at University of California, Davis School of Medicine

Date: October 20, 2022 at 4:00PM - 5:00PM

Talk Topic: How a large a collaborative research network reshapes evidence generation for pediatric care.

Landmark Ideas Series: Mihaela van der Schaar

Speaker: Mihaela van der Schaar, The John Humphrey Plummer Professor of Machine Learning, AI, and Medicine at the University of Cambridge

Date: October 3, 2022 at 4:00PM - 5:30PM

Talk Topic: Machine Learning and Revolutionizing Healthcare.

Landmark Ideas Series: Dr. Derrick Rossi (Video Available)

Speaker: Derrick Rossi, PhD, Co-founder at Moderna

Date: September 19, 2022 at 4:00PM - 5:30PM

Talk Topic: Stem Cell Science and the Genesis of New Therapeutic Strategies for Patients.

Intelligent Health Lab Series: Dr. Dave Ferrucci

Speaker: Dave Ferrucci, PhD, Founding Lead PI of IBM Watson (Former); CEO at Elemental Cognition

Date: September 12, 2022 at 4:00PM - 5:00PM

Talk Topic: The Tale of Two AI's - From Vision to Market.

Landmark Ideas Series: Dr. Vinay Prasad (Video Available)

Speaker: Vinay Prasad, MD, MPH, American Hematologist-Oncologist and Health Researcher, Associate Professor at the University of California, San Francisco

Date: May 5, 2022 at 4:00PM - 5:30PM

Talk Topic: Medical Reversal: Why 46% of What Doctors Think Is Wrong In this lecture we will talk about the rate with which medical practices are widely adopted and later found to be lacking. We will explore some of the causes and solutions. 

Landmark Ideas Series: Dr. Rob Knight (Video Available)

Speaker: Rob Knight, PhD, Co-founder at The American Gut Project

Date: March 17, 2022 at 4:00PM - 5:30PM

Talk Topic: Linking Human and Environmental Microbiomes for Health.

Landmark Ideas Series: Dr. Todd Golub (Video Available)

Speaker: Todd Golub, MD, Director of the Broad Institute at MIT and Harvard

Date: February 17, 2022 at 4:00PM - 5:30PM

Genomic Approaches to Cancer Precision Medicine Dr. Golub will present findings from his laboratory and the Broad Institute Cancer Program utilizing large-scale pre-clinical models for therapeutic target discovery and approaches to cancer precision medicine. 

Landmark Ideas Series: Envisioning Clinical Evidence Generation of the Future (Video Available)

Speaker: Amy Abernethy, MD, PhD; Former Principal Deputy Commissioner and acting Chief Information Officer of Food and Drugs of the US Food and Drug Administration (FDA), President of Clinical Studies Platforms at Verily

Date: January 20, 2022 at 4:00PM - 5:30PM

Clinical research is undergoing a major shift, as regulators and sponsors move towards continuous evidence generation to study how interventions perform over time. In this talk, we’ll explore what’s accelerating this trend, how new tools and technologies are advancing the space, and how it can ultimately enable more personalized care.

Searching for the Origin of Covid-19 (Video Available)

Speaker: Alina Chan, Molecular Biologist at the Broad Institute at MIT and Harvard University

Date: November 15, 2021 at 4:00PM - 5:30PM

In May 2020, I co-authored a preprint that asked whether SARS-CoV-2 might have emerged naturally or from a lab. The preprint propelled me into an unpredictable year-and-a-half journey of searching for the origin of Covid-19. In May 2021, I agreed to write down what I had learnt in a book that will be released on November 16, VIRAL: The Search for the Origin of Covid-19. In this Landmark talk, I will discuss the role of scientists in the investigation of how SARS-CoV-2 emerged in Wuhan in late 2019. I will also describe the available data relevant to the origin of Covid-19, and how scientists can and must play an important role in what is possibly the most important mystery of our generation. This virus will be with us forever. We need to know where it came from.

Water Quality and Child Survival (Video Available)

Speaker: Michael Kremer, PhD, 2019 Nobel Laureate, Director of the Development Innovation Lab, University Professor in Economics and the College and the Harris School of Public Policy at the University of Chicago

Date: November 4, 2021 at 4:00PM - 5:30PM

The Computational Future and Biomedicine (Video Available)

Speaker: Stephen Wolfram, PhD, Founder and CEO at Wolfram Research

Date: October 7, 2021 at 4:00PM - 5:30PM

Dr. Stephen Wolfram  –  creator of Mathematica, Wolfram|Alpha and the Wolfram Language; the author of A New Kind of Science; the originator of the Wolfram Physics Project; and the founder and CEO of Wolfram Research – will speak about the computational future and biomedicine. Dr. Wolfram will share a roadmap for recentering biomedicine around computation and give insights into harnessing data driven science to transform the biomedical landscape. This should be a relevant and an illuminating talk from one of the foremost leaders in computational health.  

People, Ideas, and Machines (Video Available)

Speaker: Enrico Coiera, PhD, Director of the Centre for Health Informatics at Australian Institute of Health Innovation

Date: April 29, 2021 at 5:00PM - 6:30PM

In an age where technology appears to rule supreme, it is easy to forget that our relationship with technology is complicated. Just as humans shape technology, it shapes us in return. It is also easy to only see things through the lens of the technologies we have to hand, and build solutions that ill fit reality. Electronic health records for example demand that clinical work bends to the needs of documentation, with the end result being burnt out clinicians who do anything but what they were taught at medical school. Algorithms built with our cleverest machine learning methods just end up making concrete the biases implicit in their data sets. Seeing human systems like healthcare as sociotechnical systems helps us understand these unintended consequences, and gives us a different lens to understand technology design and use.

The Privacy Confusion First Thoughts on Clearer Thinking (Video Available)

Speaker: Lawrence Lessig, JD, Founder of Creative Commons, Roy L. Furman Professor of Law and Leadership at Harvard Law School

Date: March 1, 2021 at 4:00PM - 5:30PM

Privacy has become a central focus of policy debates in every context. In this talk, Lessig argues that we’re conceiving of the problem in a fundamentally flawed way. Offered is a different framework, radically different but critically better. Or so it is hoped.

Precisely Practicing Medicine from 700 Trillion Points of Data (Video Available)

Speaker: Atul Butte, MD, PhD, Priscilla Chan and Mark Zuckerberg Distinguished Professor at UCSF and Chief Data Science Officer at University of California Health System

Date: February 22, 2021 at 4:00PM - 5:30PM

There is an urgent need to take what we have learned in our new data-driven era of medicine, and use it to create a new system of precision medicine, delivering the best, safest, cost-effective preventative or therapeutic intervention at the right time, for the right patients.  Dr. Butte's lab at the University of California, San Francisco builds and applies tools that convert trillions of points of molecular, clinical, and epidemiological data -- measured by researchers and clinicians over the past decade and now commonly termed “big data” -- into diagnostics, therapeutics, and new insights into disease.  Dr. Butte, a computer scientist and pediatrician, will highlight his center’s recent work on integrating electronic health records data across the entire University of California, and how analytics on this “real world data” can lead to new evidence for drug efficacy, new savings from better medication choices, and new methods to teach intelligence – real and artificial – to more precisely practice medicine. 

Prospects for Hyper-Personalized Medicine (Video Available)

Speaker: Timothy Yu, MD, PhD, Neurogeneticist and Researcher at Boston Children's Hospital

Date: January 11, 2021 at 4:00PM - 5:30PM

Genome sequencing is revolutionizing the diagnosis of rare diseases, but 95% of these conditions still lack effective therapy. With up to 7,000 distinct genetic diseases to tackle, new and creative frameworks will be necessary to meet this need. Recent advances offer the prospect of platform-based therapeutic approaches to certain genetically targetable disorders — in the right circumstances, facilitating the design and deployment of hyper-personalized drugs for conditions affecting as few as even a single patient. The scientific, clinical, ethical, and regulatory implications of these capabilities will be discussed.

Event Horizon Telescope: Imaging a Black Hole Through Global Collaboration (Video Available)

Speaker: Shep Doeleman, PhD, 2020 Breakthrough Prize Winner; Astrophysicist at Center for Astrophysics

Date: November 9, 2020 at 4:00PM - 5:30PM

What can medicine learn about collaboration and data sharing from one of the most successful team science projects of all time--creating a telescope the diameter of the earth to snap an image of a black hole? Black holes are cosmic objects so massive and dense that their gravity forms an event horizon: a region of spacetime from which nothing, not even light, can escape. Einstein's theories predict that a distant observer should see a ring of light encircling the black hole, which forms when radiation emitted by infalling hot gas is lensed by the extreme gravity. The Event Horizon Telescope (EHT) is a global array of radio dishes that forms an Earth-sized virtual telescope, which can resolve the nearest supermassive black holes where this ring feature may be measured. On April 10th, 2019, the EHT project reported success: we have imaged a black hole and have seen the predicted strong gravitational lensing that confirms the theory of General Relativity at the boundary of a black hole.  This talk will describe the project, and the global collaborative approach that produced these first results, as well as future directions that will enable real-time black hole movies.

Interoperability at Scale
Landmark Center at 401 Park Drive, 5th floor East, Boston, MA 02215

Speaker: Ricky Bloomfield, MD, Clinical and Health Informatics Lead at Apple

Date: March 2, 2020 at 4:00 PM - 5:30 PM

Healthcare has been slow to adopt scalable, interoperable, user-centric solutions as other industries have done, but technology is finally catching up with the needs of patients. Ricky will share how Apple's support and use of open standards has helped accelerate adoption across the country.

Forces Shaping the Future of the Internet
Landmark Center at 401 Park Drive, 5th floor East, Boston, MA 02215

Speaker: David Clark, PhD, MS, An Inventor of the Internet; Technical Director at MIT Internet Policy Research Initiative

Date: February 13, 2020 at 4:00PM - 5:30PM

In the early days of the Internet, technical innovation shaped its future. Today, issues of economics, market dynamics, incentives, and some fundamental aspects of networked systems shape the future. This talk will summarize eleven forces that are shaping the future of the Internet and make an argument that we are at a point of inflection in the character of the Internet, as profound as the change in the 1990’s when the Internet was commercialized.

Social Network Interventions
Landmark Center at 401 Park Drive, 5th floor East, Boston, MA 02215

Speaker: Nicholas A. Christakis, MD, PhD, MPH, Scientist and Physician at Yale University

Date: December 16, 2019 at 4:00PM - 5:30PM

Human beings choose their friends, and often their neighbors and co-workers, and they inherit their relatives; and each of the people to whom we are connected also does the same, such that, in the end, we humans assemble ourselves into face-to-face social networks. Why do we do this? How has natural selection shaped us in this regard? What role do our genes play in the topology of our social ties? And how might a deep understanding of human social network structure and function be used to intervene in the world to make it better?

Big Tech and the National Health Service: Maintaining Equity in the AI Revolution
Where: Landmark Center at 401 Park Drive, 5th floor East, Boston, MA 02215

Speaker: Maxine Mackintosh, PhD, Winston Churchill Fellow at the Alan Turing Institute and University College London

Date: October 21, 2019 at 4:00PM - 5:30PM

A day does not go by without a new framework for ethics in AI, particularly in health and social care. But when your health system is based on need versus ability to pay, yet the skills, computational power and often data lies in tech companies, from SMEs to multinationals, it can be difficult to see how a health system can digitize in an equitable and ethical manner. Maxine’s talk will share some examples of the learnings, attitudes and practical ways the UK has approached data stewardship, partnerships, “intangible assets" and transparency of health data organizations looking to work with the NHS. These examples will include learnings from DeepMind Health’s Independent Review Board, the use of consumer data in the UK for health research, and how the UK is approaching some of these discussions at a national, policy level.


Hopper RK, Abman SH, Elia EG, Avitabile CM, Yung D, Mullen MP, Austin ED, Bates A, Handler SS, Feinstein JA, Ivy DD, Kinsella JP, Mandl KD, Raj JU, Sleeper LA, . Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry. The Journal of pediatrics 2022.

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Torous J, Stern AD, Bourgeois FT. Regulatory considerations to keep pace with innovation in digital health products. NPJ digital medicine 2022.

Levy S, Wisk LE, Minegishi M, Ertman B, Lunstead J, Brogna M, Weitzman ER. Association of Screening and Brief Intervention With Substance Use in Massachusetts Middle and High Schools. JAMA network open 2022.

Nielsen M, Presti M, Sztupinszki Z, Jensen AWP, Draghi A, Chamberlain CA, Schina A, Yde CW, Wojcik J, Szallasi Z, Crowther MD, Svane IM, Donia M. Co-existing alterations of MHC class I antigen presentation and IFNγ signaling mediate acquired resistance of melanoma to post-PD-1 immunotherapy. Cancer immunology research 2022.