Intelligent Health Lab Series: Dr. Nathan Kuppermann

Speaker: Nate Kuppermann, MD, MPH, at University of California, Davis School of Medicine

Date: October 20, 2022 at 4:00PM - 5:00PM

Talk Topic: How a large a collaborative research network reshapes evidence generation for pediatric care.

Dr. Kuppermann is a Distinguished Professor of Emergency Medicine and Pediatrics, and the Bo Tomas Brofeldt Endowed Chair of the Department of Emergency Medicine at UC Davis. He is a pediatric emergency medicine (PEM) physician and clinical epidemiologist, and a leader in emergency medical services for children, particularly in multicenter research. Research foci for which he is a leading national investigator include 1) infectious emergencies in children including the laboratory evaluation of young febrile children, 2) the evaluation of children at risk of diabetic ketoacidosis-related cerebral injury, and 3) the laboratory and radiographic evaluation of the pediatric trauma patient. His focus is on clinical trials and clinical prediction rules using large cohorts of acutely ill and injured children. He has published works in all three focus areas in high-impact journals such as the New England Journal of Medicine, JAMA, BMJ, and the Lancet. Dr. Kuppermann has received more than $30 million in federal grants and contracts as a PI over the past decade, and has published more than 275 peer-reviewed publications (Hirsch Index 70). Dr. Kuppermann has been a leader in multicenter research in PEM, starting by chairing the first U.S. research network in PEM (the Pediatric Emergency Medicine Collaborative Research Committee of the AAP) from 1996-2000, and leading several investigations there. He then became one of the founding investigators and founding Chair of the Steering Committee of the Pediatric Emergency Care Applied Research Network (PECARN) since it’s inception in 2001 until late in 2008, and remains one of the 7 network PIs. He recently completed a 4-year term as Chair of the Executive Committee of the (global) Pediatric Emergency Research Network (PERN), an international consortium of PEM research networks. He has mentored scores of trainees and junior faculty members, most of whom have gone on to academic careers, many of whom have secured federally-funded grants.

Dr. Kuppermann has been recognized nationally for his research and mentorship. In 2009, Dr. Kuppermann received the Miller-Sarkin Mentoring Award from the Academic Pediatric Association, and in 2012 received the Jim Seidel Distinguished Service Award, from the Section on Emergency Medicine of the AAP for outstanding contributions to Pediatric Emergency Medicine. In 2010 and 2011, he received national research awards from the EMSC program of HRSA, the Society for Academic Emergency Medicine (SAEM), and the American College of Emergency Physicians. In 2015, he was recognized with the American College of American Physicians EBSCO/PEMSoft Achievement Award for outstanding contributions to pediatric emergency evidence-based medicine. In 2017 a PEM Scientific Research Mentoring award was named after him by the SAEM, and in 2020 he was awarded the Hibbard Williams Extraordinary Achievement Award from UC Davis Health as well as the UC Davis Faculty Distinguished Research Award from the Academic Senate, UC Davis. In 2003 he was a Fulbright Distinguished Scholar in the U.K. and in 2010 he was elected to the National Academy of Medicine. In 2022 he was the recipient of the Maureen Andrew Mentor Award from the Society for Pediatric Research.


Publications

Hopper RK, Abman SH, Elia EG, Avitabile CM, Yung D, Mullen MP, Austin ED, Bates A, Handler SS, Feinstein JA, Ivy DD, Kinsella JP, Mandl KD, Raj JU, Sleeper LA, . Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry. The Journal of pediatrics 2022.

Wang X, Zhang HG, Xiong X, Hong C, Weber GM, Brat GA, Bonzel CL, Luo Y, Duan R, Palmer NP, Hutch MR, Gutiérrez-Sacristán A, Bellazzi R, Chiovato L, Cho K, Dagliati A, Estiri H, García-Barrio N, Griffier R, Hanauer DA, Ho YL, Holmes JH, Keller MS, Klann MEng JG, L'Yi S, Lozano-Zahonero S, Maidlow SE, Makoudjou A, Malovini A, Moal B, Moore JH, Morris M, Mowery DL, Murphy SN, Neuraz A, Yuan Ngiam K, Omenn GS, Patel LP, Pedrera-Jiménez M, Prunotto A, Jebathilagam Samayamuthu M, Sanz Vidorreta FJ, Schriver ER, Schubert P, Serrano-Balazote P, South AM, Tan ALM, Tan BWL, Tibollo V, Tippmann P, Visweswaran S, Xia Z, Yuan W, Zöller D, Kohane IS, Avillach P, Guo Z, Cai T, . SurvMaximin: Robust federated approach to transporting survival risk prediction models. Journal of biomedical informatics 2022.

Torous J, Stern AD, Bourgeois FT. Regulatory considerations to keep pace with innovation in digital health products. NPJ digital medicine 2022.

Levy S, Wisk LE, Minegishi M, Ertman B, Lunstead J, Brogna M, Weitzman ER. Association of Screening and Brief Intervention With Substance Use in Massachusetts Middle and High Schools. JAMA network open 2022.

Nielsen M, Presti M, Sztupinszki Z, Jensen AWP, Draghi A, Chamberlain CA, Schina A, Yde CW, Wojcik J, Szallasi Z, Crowther MD, Svane IM, Donia M. Co-existing alterations of MHC class I antigen presentation and IFNγ signaling mediate acquired resistance of melanoma to post-PD-1 immunotherapy. Cancer immunology research 2022.