An area of CHIP pioneering innovation is federated networks, a practice which enables decentralized approaches to data distributed across sites. From our faculty’s earliest forays into the field with the Shared Pathology Information Network (The NCI funded “Napster for pathology samples”) to the first demonstration of federated research networks for biosurveillance, to development of the Shared Health Research Innovation Network (SHRINE) network.

Our program has worked with sister academic medical institutions to establish globally scalable technology, policies and procedures for sharing genomic, phenotypic and biospecimen data on broadly consented cohorts, across sites of care. We have, in partnership with our sister sites, developed two federated data sharing commons, the Genomic Research and Innovation Network (GRIN) and the Genomic Information Commons (GIC). Our faculty have developed the first query portal in the world that provides a uniform interface that enables users to retrieve genomic data, phenotypic data and biospecimen metadata in a single query. The technology, policies, and procedures that we have developed enable us to acquire additional partners and scale our federated data sharing globally.

Projects

Publications

Beinvogl B, Palmer N, Kohane I, Nurko S. Healthcare spending and utilization for pediatric Irritable Bowel Syndrome in a commercially insured population. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2021.

Wang AL, Panganiban R, Qiu W, Kho AT, Chupp G, Meyers DA, Bleecker ER, Weiss ST, Lu Q, Tantisira KG. Drug Repurposing to Treat Glucocorticoid Resistance in Asthma. Journal of personalized medicine 2021.

Beaulieu-Jones BK, Yuan W, Brat GA, Beam AL, Weber G, Ruffin M, Kohane IS. Machine learning for patient risk stratification: standing on, or looking over, the shoulders of clinicians? NPJ digital medicine 2021.

Maharaj AS, Parker J, Hopkins JP, Gournis E, Bogoch II, Rader B, Astley CM, Ivers N, Hawkins JB, VanStone N, Tuite AR, Fisman DN, Brownstein JS, Lapointe-Shaw L. The effect of seasonal respiratory virus transmission on syndromic surveillance for COVID-19 in Ontario, Canada. The Lancet. Infectious diseases 2021.