The ability to acquire and then reason over an entire spectrum of data types ranging from molecular and genomic all the way to clinical, epidemiological, environmental and social is now seen as central to improving patient care and advancing biomedical science.

This vision has led CHIP faculty to pursue interests in the methods, approaches, and tools of biomedical informatics and to an understanding that, increasingly, biomedical research and medical practice involve knowledge management and engineering and data-to-knowledge processes that can only be performed at scale by embracing the full spectrum of available data.

Labs

Cava Lab

We are a multi-disciplinary group, open to students in clinical and biomedical sciences, computer science, statistics, engineering, and related fields. We seek clarity and fairness from complex problems that necessitate interdisciplinary approaches. Our goals are to cultivate an environment for critical thinking, research creativity and open scientific collaboration. In addition, this lab is a good fit for those who wish to gain expertise in biomedical informatics and machine learning, especially when interpretability and fairness are central concerns.

Natural Language Processing Laboratory

Our mission is to develop and implement Natural Language Processing (NLP) technologies to apply to the electronic medical record.  These technologies include core NLP tasks such as relation extraction, coreference resolution, and parsing, and make use of statistical machine learning methods.  In order to use many machine learning methods, manually labeled (annotated) domain- and task-specific data is required.  To that end, we are heavily involved in many different clinical document annotation projects.  Since manual annotation is a time-consuming, painstaking, expensive process, it is also our goal to develop and use algorithms that minimize the required amount of labeled data required while maximizing the use of existing labeled data.

The Programmatic Outbreak Response and [socio-]Technical Analytics Lab (PORTAL)

PORTAL uses probabilistic modeling, data science, and “systems epidemiology” in the context of public health, with a focus on causal inference to advance infectious disease surveillance using digital disease data (e.g. search trends; news and social media).

The Registry and Informatics R&D (RIR&D) Group

The RIR&D Group is focused on the development and application of innovative, open-source, data-driven solutions to challenges faced by longitudinal disease registries and related studies. A principal focus of our group is informatics-based strategies to enhance the collection and sharing of clinical research data within the 75+ site Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, serving as a paradigm for other similar longitudinal chronic disease registries. Members of the CHIP RIR&D Group include specialists in software architecture and development for multi-site/multi-source regulatory-grade clinical research data warehousing, research data coordination, research analytics and computable phenotyping, and related IRB and regulatory/legal matters for clinical trials.

The Manrai Lab

The Manrai Lab is a team of machine learning scientists, clinicians, and biomedical data scientists working to improve medical decision making by developing computational approaches that incorporate rich and deep representations of clinical state and an individual's identity into care. Active projects include: improving genetic variant classification and quantifying risk ("penetrance") for inherited heart disease, measuring "normal" variation for blood lab biomarkers across populations focused on creatinine and kidney disease, developing semi-supervised learning approaches for multi-modal imaging, and modeling reproducibility in integrative biomedical studies using meta-science ("science of science") approaches.

The Pediatric Therapeutics and Regulatory Science Initiative

The Pediatric Therapeutics and Regulatory Science Initiative provides a forum for collaboration with academia, patients, policymakers, and industry. Its aim is to advance the development and evidence-based use of novel therapeutics for children globally.

Inclusion Body Myositis Research

The Inclusion Body Myositis Research group is dedicated to understanding and finding treatment for sporadic inclusion body myositis (s-IBM), dermatomyositis, polymyositis, and other inflammatory myopathies.

SMART Health IT

SMART Health IT advances medicine, discovery and public health through parsimonious, open standards, application programming interfaces, laws and regulation, and is best known for the SMART on FHIR API. 

Laboratory for Neuroinformatics and Neurodiagnostics (LNN)

The LNN develops computational methods for extracting digital biomarkers for brain disorders from EEG measurements. Our approach to EEG signal analysis is based in complex dynamical systems theory. Entropy measures, recurrence plot and recurrence network analysis, neural synchronization, and tensor data structures all play a role. 

Computational Epidemiology Lab

The Computational Epidemiology Lab conducts a diverse set of projects to predict patterns of disease, analyze patterns of epidemics, use of satellite data and public health surveillance tools. 

Avillach Lab

The Avillach Lab investigates translational bioinformatics, specifically in integrating multiple heterogeneous sources of clinical and genomics data in a meaningful way. 

Translational Omics Medicine Lab

The Translational Omics Medicine Lab develops methods to molecularly characterize patients for research and discovery. 

Machine Intelligence Lab

The Machine Intelligence Lab has a multidisciplinary research agenda. The research involves the conception and implementation of machine intelligence analytics tools, capable of predicting unobserved events in health care in the immediate or near future. 

Predictive Medicine Group

The Predictive Medicine Group works to develop novel approaches for predicting human health. Our diverse group of researchers, clinicians, mathematicians, computer scientists and biologists develop advanced predictive models for a wide range of applicants, including disease risk prediction, predictive pharmacovigilance, predictive health system dynamics and real-time public health surveillance. 

Publications

Chung MK, Smith MR, Lin Y, Walker DI, Jones D, Patel CJ, Kong SW. Plasma metabolomics of autism spectrum disorder and influence of shared components in proband families. Exposome 2021.

Toce MS, Hudgins JD, Yuskaitis CJ, Monuteaux MC, Bourgeois FT. National assessment of anti-epileptic drug exposures among pre-teens and adolescents, 2000-2020. Clinical toxicology (Philadelphia, Pa.) 2022.

Schuster JE, Halasa NB, Nakamura M, Levy ER, Fitzgerald JC, Young CC, Newhams MM, Bourgeois F, Staat MA, Hobbs CV, Dapul H, Feldstein LR, Jackson AM, Mack EH, Walker TC, Maddux AB, Spinella PC, Loftis LL, Kong M, Rowan CM, Bembea MM, McLaughlin GE, Hall MW, Babbitt CJ, Maamari M, Zinter MS, Cvijanovich NZ, Michelson KN, Gertz SJ, Carroll CL, Thomas NJ, Giuliano JS, Singh AR, Hymes SR, Schwarz AJ, McGuire JK, Nofziger RA, Flori HR, Clouser KN, Wellnitz K, Cullimore ML, Hume JR, Patel M, Randolph AG, . A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020. Journal of the Pediatric Infectious Diseases Society 2022.

Chen D, Gervai JZ, Póti Á, Németh E, Szeltner Z, Szikriszt B, Gyüre Z, Zámborszky J, Ceccon M, d'Adda di Fagagna F, Szallasi Z, Richardson AL, Szüts D. BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1. Nature communications 2022.

Maharaj AS, Parker J, Hopkins JP, Gournis E, Bogoch II, Rader B, Astley CM, Ivers NM, Hawkins JB, Lee L, Tuite AR, Fisman DN, Brownstein JS, Lapointe-Shaw L. Comparison of longitudinal trends in self-reported symptoms and COVID-19 case activity in Ontario, Canada. PloS one 2022.